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Safety Profiles: Side Effects Comparison
ACE-031 adverse effects: Epistaxis and telangiectasia (vascular; most common) Injection site reactions (expected; minimal) Immunogenicity (low-titre antibodies in minority) Follistatin adverse effects: Epistaxis (observed in some studies; similar to ACE-031) S
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- ACE-031 adverse effects:
- Epistaxis and telangiectasia (vascular; most common)
- Injection site reactions (expected; minimal)
- Immunogenicity (low-titre antibodies in minority)
- Follistatin adverse effects:
- Epistaxis (observed in some studies; similar to ACE-031)
- Systemic inflammatory effects (broader TGF-β inhibition consequences)
- Lower reported immunogenicity (natural human protein)
- Vascular effects: Both carry epistaxis risk due to activin inhibition; similar mechanisms
- Off-target effects: Follistatin’s broader target spectrum may create more systemic effects
- Immunogenicity: Follistatin, being a natural human protein, may be better tolerated immunologically in some systems