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Research Selection Framework: Follistatin vs ACE-031
Research question: myostatin-specific biology, mechanistic attribution, vascular-safe model, clean SMAD2/3 pathway → FST-315 10mg/kg 2×/week, pSMAD2/3 + atrogene controls, myostatin add-back reversal arm. Research question: maximum hypertrophy magnitude, activ
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- Research question: myostatin-specific biology, mechanistic attribution, vascular-safe model, clean SMAD2/3 pathway → FST-315 10mg/kg 2×/week, pSMAD2/3 + atrogene controls, myostatin add-back reversal arm.
- Research question: maximum hypertrophy magnitude, activin A/B contribution to wasting, cachexia (high activin A environment), satellite cell maximal activation → ACE-031 10mg/kg 2×/week, SMAD2/3 + SMAD1/5/8 dual measurement, vascular histology mandatory (CD31+, vWF IHC), BMP9 add-back control.
- Research question: disease-specific muscle wasting with mixed aetiology (DMD, cachexia, denervation) → both compounds in parallel arms at equimolar dose to establish myostatin-specific vs broader ActRIIB-ligand contribution to therapeutic mass restoration.
- Models: mdx C57BL/10 or C57BL/6J-mdx; LLC syngeneic cachexia; sciatic nerve transection SD rat; OVX sarcopenia C57BL/6J; aged 22-24mo C57BL/6J; hindlimb unloading; CTX injury-regeneration C57BL/6J.
- Endpoints: muscle mass (normalised to tibia length), fibre CSA (MHC-immunotyped cross-sections), MyoD+/Pax7+ satellite cell quantification, grip strength (BIO-GS-3 grip meter), rotarod, ex vivo tetanic force and specific force, pSMAD2/3 Western blot, atrogene qPCR (MuRF1/Atrogin-1), vascular histology panel for ACE-031 studies.
- 🇬🇧 UK Research Peptides: PeptidesLab UK supplies COA-verified Follistatin (FST-315) and ACE-031 for research and laboratory use. View UK stock →
- William is a research analyst at Peptides Lab UK, specialising in research peptides, laboratory compounds, and sourcing standards for high-purity peptide products.