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Real Peptides vs Core Peptides: Side-by-Side Comparison
The table below compares Real Peptides and Core Peptides across synthesis precision, purity standards, sequence verification, batch consistency, and customer transparency. The variables that matter for research-grade peptide reliability. Synthesis Scale Small-
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- The table below compares Real Peptides and Core Peptides across synthesis precision, purity standards, sequence verification, batch consistency, and customer transparency. The variables that matter for research-grade peptide reliability.
- Synthesis Scale
- Small-batch (10–50g per run)
- High-volume (200–500g per run)
- Small-batch synthesis allows real-time coupling monitoring and immediate corrective cycles, reducing sequence error rates from 10–14% to below 6% for peptides above 15 amino acids
- Purity Guarantee
- ≥98% by dual-wavelength HPLC (214 nm + 280 nm)
- ≥95% standard, ≥98% premium, single-wavelength HPLC (220 nm)
- Dual-wavelength detection captures non-peptidic impurities (solvents, salts) that single-wavelength methods miss; practical purity difference of 2–4% for complex peptides
- Sequence Verification
- MALDI-TOF MS standard for peptides >15 amino acids
- HPLC only; MS available as paid add-on
- Sequence-level MS is the only method that detects amino acid substitutions, deletions, or oxidation products that co-elute on HPLC; critical for receptor-binding or enzyme assays
- Batch Consistency Tolerance
- ±2% purity deviation between lots
- ±5% purity deviation between lots
- Tighter batch control reduces replication failures in dose-response studies; 4–5% purity drift translates to 10–15% shift in EC50 values in sensitive assays
- Stability Data
- Lot-specific stability testing with aggregate analysis
- General shelf-life guidelines, no lot-specific data
- Peptides prone to aggregation (e.g., Sermorelin, longer GHRHs) degrade unpredictably without accelerated stability testing; general guidelines don't account for batch-specific storage history
- Typical Lead Time
- 10–14 business days for custom synthesis
- 5–7 business days for stock items
- Faster turnaround reflects higher inventory and bulk pre-synthesis; small-batch custom orders require longer production windows but ensure fresh manufacture