Understand the source comparison
Post Holiday Detox NAD Glutathione Recovery Comparison
Nicotinamide Riboside (NR) NAD+ precursor. Bypasses rate-limiting salvage pathway step 300–500mg daily 48–72 hours Phase 2 trials show 40% increase in hepatic NAD+ at 500mg/day Best-evidenced NAD+ precursor for post-stress repletion N-Acetylcysteine (NAC) Prov
No winner is assigned.
This page preserves a source comparison for education. It does not add a rating, recommendation or clinical judgment.
- Nicotinamide Riboside (NR)
- NAD+ precursor. Bypasses rate-limiting salvage pathway step
- 300–500mg daily
- 48–72 hours
- Phase 2 trials show 40% increase in hepatic NAD+ at 500mg/day
- Best-evidenced NAD+ precursor for post-stress repletion
- N-Acetylcysteine (NAC)
- Provides cysteine for glutathione synthesis
- 600–1200mg twice daily
- 48–96 hours
- Meta-analysis of 26 RCTs shows 30–40% increase in intracellular GSH
- First-line glutathione precursor. Inexpensive, well-tolerated
- Liposomal Glutathione
- Direct glutathione delivery in phospholipid vesicles
- 500–1000mg daily
- 24–48 hours
- Crossover trial shows 60% bioavailability vs 10% standard oral
- Fastest GSH restoration but higher cost per dose
- Alpha-Lipoic Acid
- Regenerates both NAD+ and glutathione via redox cycling
- 300–600mg daily
- 72 hours
- Limited human data. Primarily animal studies
- Adjunct only. Insufficient as monotherapy
- IV NAD+ Infusion
- Direct NAD+ administration bypassing GI absorption
- 250–500mg per session
- Immediate (hours)
- Case series only. No controlled trials
- Expensive, lacks controlled efficacy data for recovery indication