Understand the source comparison
Peptides Help with Sarcopenia: Comparison Table
GHRP-2 20–30 minutes 2–3× daily SC injection Restores pulsatile GH release; 8–12% lean mass increase in trials Transient cortisol and prolactin elevation; hunger stimulation Best for restoring age-appropriate GH secretion patterns. Requires consistent dosing s
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This page preserves a source comparison for education. It does not add a rating, recommendation or clinical judgment.
- GHRP-2
- 20–30 minutes
- 2–3× daily SC injection
- Restores pulsatile GH release; 8–12% lean mass increase in trials
- Transient cortisol and prolactin elevation; hunger stimulation
- Best for restoring age-appropriate GH secretion patterns. Requires consistent dosing schedule
- Ipamorelin
- 2 hours
- 2× daily SC injection
- GH release without cortisol/prolactin spike; well-tolerated in elderly
- Mild injection site reaction; minimal hunger effect
- Cleanest side effect profile among GHRPs. Ideal for older adults sensitive to metabolic disruption
- MK 677
- 24 hours
- Once daily oral
- Sustained GH and IGF-1 elevation; 6–10% lean mass increase
- Increased appetite, elevated fasting glucose in 20–30% of users
- Convenient oral dosing but monitor glucose tolerance. Not suitable for pre-diabetic individuals
- 20–30 hours
- Once daily SC injection
- Direct mTOR activation; 10–15% lean mass increase when stacked with training
- Insulin resistance with chronic use; hypoglycemia risk if dosed incorrectly
- Bypasses pituitary entirely. Use cautiously and monitor fasting insulin levels
- CJC-1295 + Ipamorelin
- CJC: 6–8 days; Ipa: 2 hours
- CJC 1–2×/week + Ipa 2×/day
- Synergistic GH pulse amplitude and frequency; 12–18% lean mass in controlled studies
- Rare injection site nodules with CJC; otherwise minimal
- Gold standard stack for sarcopenia. Balances efficacy and tolerability