Understand the source comparison
Peptides Help with Hair Loss: Full Comparison
Copper Peptide (GHK-Cu) 340 Da VEGF/TGF-β upregulation, MMP activation, follicle remodelling High. Multiple RCTs showing 10–20% density increase at 24 weeks Requires lipophilic carrier; degrades in alkaline pH Gold standard for topical peptide therapy. Proven
No winner is assigned.
This page preserves a source comparison for education. It does not add a rating, recommendation or clinical judgment.
- Copper Peptide (GHK-Cu)
- 340 Da
- VEGF/TGF-β upregulation, MMP activation, follicle remodelling
- High. Multiple RCTs showing 10–20% density increase at 24 weeks
- Requires lipophilic carrier; degrades in alkaline pH
- Gold standard for topical peptide therapy. Proven efficacy with manageable formulation requirements
- Thymosin Beta-4 (Tβ4)
- 4,963 Da
- Angiogenesis, endothelial migration, anti-inflammatory signalling
- Moderate. Pilot studies show 15–20% improvement but require injection
- Cannot penetrate topically; requires liposomal encapsulation or subcutaneous delivery
- Mechanistically sound but delivery challenges limit practical use outside clinical settings
- Biomimetic Hexapeptides (e.g. Capixyl)
- 600–800 Da
- 5α-reductase inhibition, cytokine modulation
- Low. Manufacturer trials only, no independent replication
- Molecular weight borderline for penetration; requires penetration enhancers
- Promising theoretical mechanism but lacks peer-reviewed validation outside sponsored trials
- Palmitoyl Tetrapeptide-7
- 802 Da
- IL-6 suppression, reduces follicular inflammation
- Low. Evidence primarily for skin aging, not hair-specific
- Exceeds 500 Da threshold; penetration highly formulation-dependent
- Indirect benefit through inflammation reduction but not a primary hair growth peptide