Understand the source comparison
Peptides for Sleep: Full Compound Comparison
DSIP (Delta Sleep-Inducing Peptide) Enhances delta wave activity during slow-wave sleep; exact receptor target unclear 25mcg–1mg IV or intranasal Extremely short (15 min plasma); unstable after reconstitution Moderate. Several small human trials in 1970s–1990s
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- DSIP (Delta Sleep-Inducing Peptide)
- Enhances delta wave activity during slow-wave sleep; exact receptor target unclear
- 25mcg–1mg IV or intranasal
- Extremely short (15 min plasma); unstable after reconstitution
- Moderate. Several small human trials in 1970s–1990s, limited replication
- Strongest evidence for slow-wave sleep enhancement but impractical dosing and poor stability limit real-world use
- Epithalon (Epitalon)
- Upregulates pineal melatonin production; may restore circadian rhythm in aging
- 5–10mg subcutaneous daily for 10–20 days
- Moderate stability; use within 21 days of reconstitution
- Low. Primarily preclinical rodent studies, limited human data
- Best mechanistic fit for circadian phase delay or age-related melatonin decline but needs larger trials
- Selank
- Modulates GABAergic and serotonergic signaling; reduces cortisol and anxiety-driven arousal
- 600mcg intranasal 2× daily
- Unusually stable; retains activity 30 days at room temp
- Moderate. Multiple human trials for anxiety with sleep as secondary outcome
- Most robust evidence for stress-driven insomnia; works upstream by lowering HPA axis activation rather than inducing sedation
- Thymalin
- Immune modulation via thymus peptide fractions; indirect sleep benefit through inflammation reduction
- 5–10mg subcutaneous 2–3× weekly
- Stable; use within 28 days of reconstitution
- Low for sleep specifically. Evidence exists for immune support, not direct sleep modulation
- Not a primary sleep peptide but may improve sleep quality secondarily in conditions where chronic inflammation disrupts sleep architecture