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Peptides for Plantar Fasciitis: Comparison of Mechanisms
BPC-157 VEGF upregulation, angiogenesis, fibroblast activation Increases collagen synthesis, promotes neovascularisation in avascular tissue Rat Achilles tendon: 40% faster healing vs control (Journal of Physiology and Pharmacology) Subcutaneous injection near
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- BPC-157
- VEGF upregulation, angiogenesis, fibroblast activation
- Increases collagen synthesis, promotes neovascularisation in avascular tissue
- Rat Achilles tendon: 40% faster healing vs control (Journal of Physiology and Pharmacology)
- Subcutaneous injection near injury site, 200–500mcg daily
- Strongest evidence for tendon/ligament repair; no human RCTs for fascia
- TB-500 (Thymosin Beta-4)
- Actin binding, cell migration, anti-inflammatory modulation
- Promotes endothelial and fibroblast migration to wound, reduces fibrosis
- Equine tendon injury: reduced lameness, increased tensile strength (veterinary trials)
- Subcutaneous or intramuscular, 2–5mg twice weekly
- Established veterinary use; human data limited to case reports
- Corticosteroid Injection
- COX-2 inhibition, broad anti-inflammatory
- Suppresses inflammation universally, no tissue repair promotion
- Plantar fasciitis: short-term pain relief, no difference vs placebo at 6 months (Cochrane Review)
- Local injection
- Symptom management only; does not address collagen deficit
- Platelet-Rich Plasma (PRP)
- Growth factor delivery (PDGF, TGF-β, IGF-1)
- Stimulates collagen deposition, modest angiogenesis
- Mixed results in fascia; 60% improvement vs 20% placebo in small trials
- Ultrasound-guided injection
- Variable quality; depends on platelet concentration
- Collagen Supplementation (Oral)
- Provides amino acid precursors for synthesis
- Supplies glycine, proline, hydroxyproline for collagen production
- No direct fascia studies; some evidence in Achilles tendinopathy
- Oral, 10–15g daily
- Indirect support; bioavailability to fascia unclear