Understand the source comparison
Peptides for Life Extension Protocol Evidence Guide: Type Comparison
Thymic Peptides (Thymalin) T-cell proliferation, immune senescence reversal Russian clinical trials showing restored CD4/CD8 ratios in elderly patients 10mg IM daily × 10 days, 1–2 cycles/year Strongest evidence for immune system restoration in aging populatio
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- Thymic Peptides (Thymalin)
- T-cell proliferation, immune senescence reversal
- Russian clinical trials showing restored CD4/CD8 ratios in elderly patients
- 10mg IM daily × 10 days, 1–2 cycles/year
- Strongest evidence for immune system restoration in aging populations. Limited Western replication remains the caveat
- Growth Hormone Secretagogues (MK 677)
- IGF-1 elevation, lean mass preservation, mitochondrial function
- FDA-reviewed Phase III data in sarcopenia, multiple peer-reviewed trials
- 25mg oral daily (continuous or cycled)
- Robust safety and efficacy data for body composition and metabolic markers. Longevity benefit is correlational, not proven
- Telomerase Activators (Epitalon)
- Telomerase upregulation, cellular replicative capacity
- Single long-term observational study showing reduced all-cause mortality
- 10mg subQ daily × 10 days, 1–2 cycles/year
- Most direct evidence for mortality reduction in humans. Replication needed, mechanism not fully confirmed
- Nootropic Peptides (Cerebrolysin, Dihexa)
- Neuroplasticity, BDNF upregulation, cognitive resilience
- Cerebrolysin has stroke recovery trials; Dihexa remains animal-only
- Varies by compound. Cerebrolysin 30ml IV, Dihexa 1–5mg subQ (extrapolated)
- Cognitive enhancement ≠ lifespan extension, but preventing neurodegeneration impacts healthspan significantly
- Tissue Repair Peptides (BPC-157, TB-500)
- Angiogenesis, wound healing, stem cell activation
- No published human trials. Extensive rodent data only
- 250–500mcg subQ BID (extrapolated from animal dose)
- Mechanism is sound, safety profile appears favorable in self-experimentation reports. Clinical validation remains absent