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Peptides for Insomnia: Research Comparison
DSIP (Delta Sleep-Inducing Peptide) GABA-B sensitization, delta-opioid modulation Increases slow-wave sleep by 20–30%, preserves REM 15–30 minutes Small-batch synthesis required for sequence fidelity MK 677 (Ibutamoren) Ghrelin receptor agonist, increases GH/I
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- DSIP (Delta Sleep-Inducing Peptide)
- GABA-B sensitization, delta-opioid modulation
- Increases slow-wave sleep by 20–30%, preserves REM
- 15–30 minutes
- Small-batch synthesis required for sequence fidelity
- MK 677 (Ibutamoren)
- Ghrelin receptor agonist, increases GH/IGF-1
- Increases REM by 50%, Stage 4 sleep by 20%
- 4–6 hours (active), 24 hours (metabolite effects)
- Available as research compound through verified labs
- Thymalin
- Immune-modulated circadian regulation, AANAT expression
- Normalizes circadian phase delays, improves sleep onset
- 2–4 hours
- Thymalin via Real Peptides
- Cerebrolysin
- Cholinergic pathway support, neurotrophic factors
- Improves sleep efficiency by 12–18% in vascular dementia models
- 2.5 hours
- Cerebrolysin via Real Peptides
- Dihexa
- Enhances BDNF signaling, acetylcholine modulation
- Indirect: supports REM consolidation through cholinergic tone
- 2–3 hours
- Dihexa via Real Peptides