Understand the source comparison
Peptides for Insomnia Chronic Protocol: Evidence Comparison
DSIP GABA-A receptor modulation, increased chloride conductance 25–50mcg subcutaneous 60–90 min before sleep Sleep latency reduction within 3–7 days Moderate. Multiple small RCTs, limited replication Best for sleep-onset insomnia with normal melatonin levels S
No winner is assigned.
This page preserves a source comparison for education. It does not add a rating, recommendation or clinical judgment.
- DSIP
- GABA-A receptor modulation, increased chloride conductance
- 25–50mcg subcutaneous 60–90 min before sleep
- Sleep latency reduction within 3–7 days
- Moderate. Multiple small RCTs, limited replication
- Best for sleep-onset insomnia with normal melatonin levels
- Selank
- BDNF upregulation, enkephalin preservation, GABAergic tone enhancement
- 750mcg intranasal once daily (morning)
- Anxiety reduction in 7–10 days, sleep improvement in 10–14 days
- Moderate. Russian clinical trials, limited Western validation
- Best for anxiety-driven insomnia with hyperarousal
- Epithalon
- Telomerase activation in pinealocytes, melatonin synthesis restoration
- 5–10mg subcutaneous early evening, 10 consecutive days
- Melatonin normalization in 2–4 weeks
- Low-Moderate. Gerontology trials, small sample sizes
- Best for age-related insomnia (60+) with documented melatonin decline
- Melatonin (comparison)
- Exogenous melatonin receptor agonism
- 0.5–3mg oral 30–60 min before sleep
- Immediate (same night)
- High. Extensive meta-analyses, FDA-recognized
- Effective for circadian phase delay, less effective for sleep maintenance