Understand the source comparison
Peptides for Increasing Growth Hormone Naturally: Research Evidence Comparison
GHRP-2 Ghrelin receptor agonist ~20–30 minutes 100–300mcg 2–3x daily High (4–6x baseline) 1.8–2.7x at 8–12 weeks Transient hunger, mild water retention Most potent acute GH response; preserves pulsatility Ipamorelin Selective ghrelin agonist ~2 hours 200–300mc
No winner is assigned.
This page preserves a source comparison for education. It does not add a rating, recommendation or clinical judgment.
- GHRP-2
- Ghrelin receptor agonist
- ~20–30 minutes
- 100–300mcg 2–3x daily
- High (4–6x baseline)
- 1.8–2.7x at 8–12 weeks
- Transient hunger, mild water retention
- Most potent acute GH response; preserves pulsatility
- Ipamorelin
- Selective ghrelin agonist
- ~2 hours
- 200–300mcg 2–3x daily
- Moderate (3–4x baseline)
- 1.5–2.0x at 8–12 weeks
- Minimal. No cortisol/prolactin spike
- Cleanest side effect profile; ideal for prolonged use
- CJC-1295 (DAC)
- GHRH analog, albumin-bound
- ~8 days
- 1–2mg weekly
- Sustained baseline elevation
- 2.0–3.0x sustained
- Injection site nodules (rare)
- Long-acting; best paired with GHRP for pulse preservation
- Hexarelin
- Potent ghrelin agonist
- ~70 minutes
- 100–200mcg 2x daily
- Very high (6–8x baseline)
- 2.5–3.5x at 4–8 weeks
- Desensitization, cortisol elevation
- Strongest acute effect; not suitable for chronic protocols
- MK-677
- Oral GHSR-1a agonist
- ~24 hours
- 10–25mg once daily
- Moderate sustained
- 1.4–1.9x at 8 weeks
- Appetite increase, insulin resistance risk
- Oral convenience; less pronounced pulsatility