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Peptides for Erectile Dysfunction: Mechanism Comparison
BPC-157 Endothelial repair, VEGF upregulation, eNOS activation 4–8 weeks (cumulative vascular repair) J Physiol Pharmacol (2019). Accelerated endothelial healing in vascular injury models 250–500 mcg subcutaneous daily Best for vascular ED. Rebuilds endothelia
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- BPC-157
- Endothelial repair, VEGF upregulation, eNOS activation
- 4–8 weeks (cumulative vascular repair)
- J Physiol Pharmacol (2019). Accelerated endothelial healing in vascular injury models
- 250–500 mcg subcutaneous daily
- Best for vascular ED. Rebuilds endothelial function, doesn't produce acute erections
- PT-141 (Bremelanotide)
- Melanocortin receptor agonist (MC4R/MC3R), central arousal initiation
- 45–60 minutes (acute CNS effect)
- J Sex Med (2019) Phase 3 trial. Significant improvement in arousal and erectile scores vs placebo
- 1.75 mg subcutaneous 45–60 min before activity
- Best for psychogenic ED or libido deficits. Generates arousal, not just vascular response
- GHRP-6
- Growth hormone secretagogue, supports endogenous testosterone and IGF-1
- 8–12 weeks (hormonal restoration)
- Growth Horm IGF Res (2020). 4–6x GH elevation, sustained IGF-1 increase
- 100–300 mcg subcutaneous 2–3x daily fasted
- Best for hormonal ED. Addresses low testosterone and growth hormone deficiency
- Sildenafil (PDE5 inhibitor)
- Blocks PDE5 enzyme, maintains cGMP, requires intact arousal and vascular function
- 30–60 minutes (acute enzyme inhibition)
- Multiple RCTs since 1998. Effective when arousal pathways are intact
- 25–100 mg oral 30–60 min before activity
- Only effective if arousal and nitric oxide synthesis are already functional