Understand the source comparison
Peptides for Concussion Healing Protocol Evidence Guide: Class Comparison
Cerebrolysin BDNF/NGF upregulation, neurotrophic support Phase III trials in moderate TBI; Cochrane review positive for stroke recovery 30–50mL IV daily × 21 days Confirmed (intravenous delivery bypasses BBB) Strongest clinical evidence base; IV administration
No winner is assigned.
This page preserves a source comparison for education. It does not add a rating, recommendation or clinical judgment.
- Cerebrolysin
- BDNF/NGF upregulation, neurotrophic support
- Phase III trials in moderate TBI; Cochrane review positive for stroke recovery
- 30–50mL IV daily × 21 days
- Confirmed (intravenous delivery bypasses BBB)
- Strongest clinical evidence base; IV administration limits practical use outside clinical settings
- Semax
- ACTH fragment; modulates AMPA receptors and reduces excitotoxicity
- Phase II/III in stroke; no direct TBI trials
- 0.1% intranasal, 2–3 drops per nostril 2×/day
- Intranasal delivery achieves CNS penetration via olfactory pathway
- Mechanistically relevant; stroke data suggests cognitive benefit but TBI-specific validation lacking
- BPC-157
- Microglial polarisation; angiogenesis promotion
- Zero human TBI trials; rat/mouse IP and intracranial injection only
- 250–500mcg SC 2×/day (extrapolated from rodent mg/kg)
- Unconfirmed in humans; all efficacy data uses direct CNS injection in animals
- Compelling preclinical data; human BBB penetration and bioavailability remain unproven
- Dihexa
- HGF/c-Met pathway activation; synaptic density enhancement
- No human trials in any indication
- 0.5–2mg oral daily (extrapolated)
- Lipophilic structure suggests BBB crossing; not confirmed in vivo
- Potent cognitive effects in animal models; complete absence of human safety/efficacy data
- Thymosin Beta-4 / TB-500
- Actin regulation; reduces neuroinflammation and promotes remyelination
- Phase I safety only; no TBI-specific trials
- 2–5mg SC 2×/week
- Limited BBB penetration; primarily peripheral anti-inflammatory
- Peripheral tissue repair well-documented; CNS effects speculative