Understand the source comparison
Peptides for Burn Healing Protocol Evidence Guide: Comparison Table
Before integrating any peptide into research protocols, understanding their distinct mechanisms, evidence quality, and limitations is critical. BPC-157 VEGF receptor activation → angiogenesis and epithelialization Moderate (20+ rodent studies, no human trials)
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This page preserves a source comparison for education. It does not add a rating, recommendation or clinical judgment.
- Before integrating any peptide into research protocols, understanding their distinct mechanisms, evidence quality, and limitations is critical.
- BPC-157
- VEGF receptor activation → angiogenesis and epithelialization
- Moderate (20+ rodent studies, no human trials)
- Subcutaneous injection near wound site
- 10–100 mcg/kg daily in rodents (human equivalent: 100–150 mcg/day)
- Strongest evidence for deep partial-thickness and full-thickness burns; requires systemic administration for effect
- TB-500
- Actin regulation → cell migration; downregulates TNF-alpha and IL-6
- Moderate (15+ studies, primarily rodent models)
- Subcutaneous injection, systemic effect
- 6 mg/kg twice weekly in rodents (human equivalent: 5–7 mg/injection)
- Most effective during proliferative phase (days 4–14); anti-inflammatory properties may reduce hypertrophic scarring
- GHK-Cu
- Copper delivery + decorin upregulation → organized collagen deposition
- High for partial-thickness (47 studies reviewed); low for full-thickness
- Topical application at wound site
- 1–5% concentration in topical gel or cream
- Best evidence for superficial and partial-thickness burns; limited efficacy when dermal structures are destroyed