Understand the source comparison
Peptides for Anxiety: Comparison
Selank GABAergic modulation, monoamine metabolism 4 RCTs (n=312 total) 0.15% solution, 3 drops per nostril 2× daily Intranasal Modest evidence for short-term anxiety reduction. Effect size is clinically detectable but not transformative Cerebrolysin Neuroplast
No winner is assigned.
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- Selank
- GABAergic modulation, monoamine metabolism
- 4 RCTs (n=312 total)
- 0.15% solution, 3 drops per nostril 2× daily
- Intranasal
- Modest evidence for short-term anxiety reduction. Effect size is clinically detectable but not transformative
- Cerebrolysin
- Neuroplasticity enhancement, anti-inflammatory
- 2 trials in comorbid anxiety/MCI (n=132 total)
- 5–10 mL IV 5 days/week for 4 weeks
- Intravenous
- Limited anxiety-specific data. Effects appear secondary to cognitive improvement
- Dihexa
- HGF receptor agonism, synaptogenesis
- None
- Not established for anxiety
- Subcutaneous (research models)
- Promising preclinical neuroplasticity data but zero human anxiety trials. Speculative at best
- Thymalin
- HPA axis modulation, immune regulation
- Animal models only
- Cortisol-lowering effects in rodents do not confirm anxiolytic efficacy in humans
- BPC-157
- Tissue repair, GABAergic influence (theoretical)
- Subcutaneous or oral
- No published evidence supporting anxiety-specific use. Mechanism is theoretical