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Peptides for Ankle Sprain Protocol: Peptide Comparison
BPC-157 Fibroblast migration via F-actin cytoskeleton modulation Rodent tendon studies show 61% tensile strength improvement at day 14 (Journal of Physiology and Pharmacology, 2020) 200–500 mcg daily, subcutaneous, 14–21 days Lyophilized: −20°C; Reconstituted:
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- BPC-157
- Fibroblast migration via F-actin cytoskeleton modulation
- Rodent tendon studies show 61% tensile strength improvement at day 14 (Journal of Physiology and Pharmacology, 2020)
- 200–500 mcg daily, subcutaneous, 14–21 days
- Lyophilized: −20°C; Reconstituted: 2–8°C, 28 days
- Best acute-phase evidence; targets collagen quality
- TB-500
- Actin-binding protein that promotes cell migration and angiogenesis
- Equine tendon studies show 34% faster return to soundness (Am J Vet Res, 2018)
- 2–5mg weekly, subcutaneous, 2–4 weeks
- Strong angiogenesis data; longer half-life than BPC
- Thymalin
- Thymic peptide that modulates immune response and tissue repair
- Primarily studied for immune function; limited ligament-specific data
- Varies; typically 5–10mg per protocol
- Immune modulation may support repair; less ligament-specific