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Peptides and Low Dose Naltrexone LDN Synergy: Protocol Comparison
Evening LDN + Morning Peptide 9–11 PM 10 AM–12 PM next day 11–13 hours (full 6-beta-naltrexol clearance) Opioid-modulating peptides (BPC-157, Thymalin, DSIP) Gold standard. Preserves LDN's endorphin rebound mechanism while ensuring peptide efficacy at full dos
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- Evening LDN + Morning Peptide
- 9–11 PM
- 10 AM–12 PM next day
- 11–13 hours (full 6-beta-naltrexol clearance)
- Opioid-modulating peptides (BPC-157, Thymalin, DSIP)
- Gold standard. Preserves LDN's endorphin rebound mechanism while ensuring peptide efficacy at full dose
- Morning LDN + Evening Peptide
- 6–8 AM
- 6–8 PM same day
- 10–12 hours (partial clearance)
- Peptides requiring evening dosing for other reasons
- Functional but suboptimal. Disrupts overnight endorphin rebound timing
- Concurrent Dosing (No Timing Separation)
- Any time
- Same time as LDN
- 0 hours (direct antagonism)
- Receptor-independent peptides only (MK-677, Tesofensine, GLP-1 agonists)
- Viable only for non-opioid peptides. Causes 40–60% efficacy loss for opioid-modulating compounds