Understand the source comparison
Peptide Sequences for Reverse Aging: Mechanism Comparison
GHK-Cu Collagen gene upregulation, MMP activation Extracellular matrix remodeling 1–2mg/day subcutaneous, 12 weeks 70% increase in collagen density (fibroblast studies); 18% improvement in cutometric elasticity Best evidence for dermal aging reversal; localize
No winner is assigned.
This page preserves a source comparison for education. It does not add a rating, recommendation or clinical judgment.
- GHK-Cu
- Collagen gene upregulation, MMP activation
- Extracellular matrix remodeling
- 1–2mg/day subcutaneous, 12 weeks
- 70% increase in collagen density (fibroblast studies); 18% improvement in cutometric elasticity
- Best evidence for dermal aging reversal; localized effects dominate
- Epithalon
- Telomerase activation (hTERT gene)
- Telomere length preservation
- 5–10mg/day for 10–20 days, 2–4x/year
- 33% increase in mean telomere length in PBLs; improved circadian melatonin rhythm
- Strong mechanistic data; systemic anti-aging effects require long-term studies
- Thymosin Alpha-1
- T-cell differentiation, immune modulation
- Thymic function restoration
- 1.6mg twice weekly, 8–12 weeks
- 34% reduction in IL-6; increased CD4+/CD8+ counts in aged populations
- Addresses immunosenescence directly; effects on healthspan better documented than lifespan
- BPC-157
- Angiogenesis, VEGF upregulation
- Tissue repair, gut-brain axis
- 250–500mcg/day, 4–8 weeks
- Accelerated wound healing in animal models; no human aging biomarker studies
- Primarily tissue repair, not aging-specific; evidence base is preclinical
- CJC-1295/Ipamorelin
- GH secretagogue (pituitary stimulation)
- Growth hormone axis
- 100mcg each, 3x/week before bed
- Increased IGF-1 by 60–90%; improved lean mass and sleep quality
- Indirect aging effects via GH axis; not a primary anti-aging peptide