Understand the source comparison
Peptide Combinations: Preservation vs Acceleration
CJC-1295/Ipamorelin GH pulse amplification Preserves 90–95% lean mass in deficit Moderate. Indirect via elevated GH 45–60 min pre-training Gold standard for recomposition. Short half-life allows precise timing alignment with training MK-677 (Inutamoren) Ghreli
No winner is assigned.
This page preserves a source comparison for education. It does not add a rating, recommendation or clinical judgment.
- CJC-1295/Ipamorelin
- GH pulse amplification
- Preserves 90–95% lean mass in deficit
- Moderate. Indirect via elevated GH
- 45–60 min pre-training
- Gold standard for recomposition. Short half-life allows precise timing alignment with training
- MK-677 (Inutamoren)
- Ghrelin receptor agonist
- Strong preservation + modest anabolic effect even in deficit
- Moderate to strong. Sustained GH elevation increases FFA oxidation
- Evening dose or morning fasted cardio
- Best for sustained baseline elevation. Pair with short-acting stack for dual coverage
- Tesofensine
- Triple monoamine reuptake inhibitor
- Neutral. Does not prevent catabolism
- Strong. 10–15% increase in REE independent of activity
- Morning dose, 30–60 min pre-fasted cardio
- Accelerates fat oxidation but offers zero muscle protection. Must stack with GH secretagogue
- CJC/Ipa + MK-677 + Tesofensine
- Multi-pathway synergy
- Excellent preservation due to GH/IGF-1 elevation
- Strongest combination. Addresses both substrate shift and energy expenditure
- Stagger: Tesofensine AM, CJC/Ipa pre-training, MK-677 PM
- Maximum deficit synergy but requires precise macronutrient timing to avoid muscle loss from appetite suppression
- Survodutide (GLP-1/Glucagon dual agonist)
- Glucagon increases lipolysis; GLP-1 reduces intake
- Moderate. Better than GLP-1 monotherapy, worse than GH secretagogues
- Very strong. Glucagon component directly signals adipocyte lipase
- Once weekly dosing. Timing less critical due to 7-day half-life
- Emerging option for aggressive cuts. survodutide research shows 15–18% body weight reduction at 24 weeks