Understand the source comparison
P21 Peptide vs p21 Protein: Full Comparison
Molecular Weight ~2.4 kDa (23 amino acids) ~21 kDa (164 amino acids) P21 peptide is 8–9× smaller; crosses BBB readily Primary Mechanism NGF pathway activation, hippocampal neurogenesis CDK inhibition, cell cycle arrest at G1/S checkpoint Entirely different bio
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This page preserves a source comparison for education. It does not add a rating, recommendation or clinical judgment.
- Molecular Weight
- ~2.4 kDa (23 amino acids)
- ~21 kDa (164 amino acids)
- P21 peptide is 8–9× smaller; crosses BBB readily
- Primary Mechanism
- NGF pathway activation, hippocampal neurogenesis
- CDK inhibition, cell cycle arrest at G1/S checkpoint
- Entirely different biological roles
- Research Applications
- Cognitive enhancement, neuroprotection, traumatic brain injury recovery
- Tumour suppression, DNA damage response, senescence studies
- Administration Route
- Intranasal (preferred), subcutaneous
- In vitro assays, recombinant protein for cell culture
- P21 peptide designed for in vivo CNS delivery
- Storage (Lyophilised)
- −20°C, reconstitute in bacteriostatic water
- −80°C as recombinant liquid in glycerol buffer
- Different stability profiles
- Gene/Origin
- Synthetic analogue of CNTF amino acid segment
- Encoded by CDKN1A gene (human chromosome 6)
- Peptide is fully synthetic; protein is naturally occurring