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NAD+ Studied: NAD Decline Research Comparison
Harvard Medical School (2019) NMN supplementation in aged mice Skeletal muscle NAD+ concentration 12 months NAD+ levels increased 40% in muscle tissue; mitochondrial function improved 25% vs control NMN restored NAD+ in metabolically active tissues but require
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- Harvard Medical School (2019)
- NMN supplementation in aged mice
- Skeletal muscle NAD+ concentration
- 12 months
- NAD+ levels increased 40% in muscle tissue; mitochondrial function improved 25% vs control
- NMN restored NAD+ in metabolically active tissues but required sustained dosing. No residual benefit after washout
- Buck Institute CD38 Inhibition Study (2020)
- CD38 inhibitor (78c) in aged mice
- Whole-body NAD+ levels
- 6 months
- NAD+ increased 30–40% across liver, brain, and kidney; CD38 expression reduced 70%
- Targeting NAD+ degradation may be more effective than precursor supplementation alone
- Science PARP Study (2018)
- PARP inhibitor in aged mice
- NAD+ concentration and lifespan
- 24 months
- NAD+ restored to youthful levels in liver; 15% lifespan extension vs control group
- PARP inhibition preserved NAD+ but required careful dosing. Excessive inhibition impaired DNA repair capacity
- Human NR Trial (Elysium Health, 2017)
- NR supplementation in healthy adults
- Blood NAD+ levels
- 8 weeks
- NAD+ increased 60% in whole blood; no change in muscle biopsy samples
- Blood NAD+ elevation doesn't guarantee tissue-level increases. Compartmentalization matters