Understand the source comparison
NAD+ Delivery Methods: Bioavailability Comparison
| Delivery Method | Bioavailability | Time to Peak Plasma Concentration | Dosing Frequency | Cost per Month | Primary Use Case | Professional Assessment ||—|—|—|—|—|—|| Oral NAD+ Capsules | <5% (degraded by gut enzymes) | Not measurable (minimal absorption) |
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This page preserves a source comparison for education. It does not add a rating, recommendation or clinical judgment.
- | Delivery Method | Bioavailability | Time to Peak Plasma Concentration | Dosing Frequency | Cost per Month | Primary Use Case | Professional Assessment ||—|—|—|—|—|—|| Oral NAD+ Capsules | <5% (degraded by gut enzymes) | Not measurable (minimal absorption) | Daily | $30–$60 | None. Avoid this method | Ineffective due to first-pass metabolism; NADase enzymes destroy NAD+ before systemic absorption || Sublingual NMN | 30–40% (bypasses first-pass) | 45–90 minutes | Daily (250–500mg) | $60–$120 | Most practical for daily home protocols | Best balance of convenience and efficacy; one-step conversion to NAD+ in target tissues || Sublingual NR | 35–45% (crosses BBB efficiently) | 60–120 minutes | Daily (300–600mg) | $70–$140 | Cognitive aging and neuroprotection | Superior blood-brain barrier penetration; requires two-step conversion but reaches CNS effectively || IV NAD+ Infusion | 95–100% (direct systemic delivery) | 30–60 minutes | Weekly or biweekly (500–1000mg) | $800–$2000 | Clinical a