Understand the source comparison
LL-37 Delivery Methods: Topical vs Subcutaneous Comparison
Before writing the table, understand what it shows: this comparison maps delivery method against concentration range, penetration depth, reapplication frequency, and clinical context. Each method suits different wound types. Topical (direct application) 1–10 μ
No winner is assigned.
This page preserves a source comparison for education. It does not add a rating, recommendation or clinical judgment.
- Before writing the table, understand what it shows: this comparison maps delivery method against concentration range, penetration depth, reapplication frequency, and clinical context. Each method suits different wound types.
- Topical (direct application)
- 1–10 μg/mL
- Superficial (epidermis and upper dermis)
- Every 12–24 hours
- Partial-thickness wounds, abrasions, post-surgical incisions
- Best for surface wounds where peptide can contact keratinocytes directly. Requires moisture-retentive dressing to prevent evaporation
- Subcutaneous injection (peri-wound)
- 0.5–5 mg/mL
- Deep dermal and subcutaneous tissue
- Every 24–48 hours
- Full-thickness wounds, chronic ulcers, deep tissue injuries
- Delivers higher peptide concentration to wound margins and deeper tissue layers. Useful when biofilm or necrotic tissue limits topical penetration
- Hydrogel carrier (embedded peptide)
- 5–20 μg/mL
- Sustained release over 24–72 hours
- Single application per dressing change
- Chronic wounds requiring extended peptide exposure
- Maintains therapeutic concentration longer than direct topical application. Ideal for wounds that can't be re-dressed frequently