Understand the source comparison
Increasing Growth Hormone Naturally Peptides: Compound Comparison
CJC-1295 (with DAC) GHRH receptor agonist 6–8 days Sustained GH elevation with weekly dosing Requires injection; less precise timing control Best for research protocols prioritising convenience and steady-state GH elevation Ipamorelin Selective ghrelin recepto
No winner is assigned.
This page preserves a source comparison for education. It does not add a rating, recommendation or clinical judgment.
- CJC-1295 (with DAC)
- GHRH receptor agonist
- 6–8 days
- Sustained GH elevation with weekly dosing
- Requires injection; less precise timing control
- Best for research protocols prioritising convenience and steady-state GH elevation
- Ipamorelin
- Selective ghrelin receptor agonist
- 2 hours
- No cortisol or prolactin spike; clean GH release
- Short half-life requires frequent dosing (2–3× daily for peak effect)
- Ideal for timing-specific protocols and combination stacks with CJC-1295
- Hexarelin
- Non-selective ghrelin agonist
- 1.5 hours
- Most potent acute GH spike (10–15× baseline)
- Rapid receptor desensitisation; requires cycling
- Suitable for short-term intensive protocols; not for continuous use
- MK-677 (Ibutamoren)
- Oral ghrelin mimetic
- 24 hours
- Oral administration; sustained 24-hour GH elevation
- Increases appetite; mild water retention in some subjects
- Best for researchers needing oral bioavailability or studying appetite-related pathways
- GHRP-2
- Ghrelin receptor agonist
- 20 minutes
- Strong GH pulse with minimal prolactin elevation
- Increases hunger and cortisol at higher doses
- Effective but less selective than ipamorelin; second-tier choice for most protocols