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Increase Testosterone Naturally with Peptides: Research Compound Comparison
CJC-1295 + Ipamorelin GHRH analog + selective ghrelin mimetic; synergistic GH pulse amplification → IGF-1 → Leydig cell stimulation 2 mg CJC weekly + 200–300 mcg ipamorelin 1–2× daily CJC: 6–8 days; Ipamorelin: 2 hours 18–22% increase at 12 weeks (JCEM 2019) M
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- CJC-1295 + Ipamorelin
- GHRH analog + selective ghrelin mimetic; synergistic GH pulse amplification → IGF-1 → Leydig cell stimulation
- 2 mg CJC weekly + 200–300 mcg ipamorelin 1–2× daily
- CJC: 6–8 days; Ipamorelin: 2 hours
- 18–22% increase at 12 weeks (JCEM 2019)
- Most researched combination for clean upstream testosterone support without HPG suppression
- Gonadorelin (GnRH)
- Direct pituitary LH/FSH stimulation; bypasses hypothalamus to signal testicular steroidogenesis
- 100 mcg every 90 min (pulsatile pump)
- 2–4 minutes
- Restores physiological range in hypogonadal men (Johns Hopkins 2020)
- Effective but impractical dosing frequency; requires pump or 8–12 daily injections
- MK 677 (Ibutamoren)
- Oral ghrelin mimetic; 24-hour GH elevation through continuous GHS-R1a activation
- 25 mg once daily
- 24 hours
- 10–15% increase at 12–16 weeks
- Convenient oral dosing but appetite increase and insulin resistance risk limit use in lean optimization protocols
- Hexarelin
- Non-selective ghrelin analog; stimulates GH but also cortisol and prolactin pathways
- 100 mcg 2–3× daily
- 70 minutes
- Minimal direct testosterone effect; GH increase sufficient for IGF-1 mediation
- Fallen out of favor due to prolactin elevation; ipamorelin selectivity is superior