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Peptide Therapy GuideClear peptide education

Understand the source comparison

Hydrophilic vs Hydrophobic Residues

Hydrophilic Lys, Arg, Asp, Glu, His Increase solubility Hydrophobic Leu, Ile, Val, Phe, Trp, Tyr Reduce solubility Neutral Gly, Ala, Ser, Thr, Asn, Gln, Pro Context-dependent

No winner is assigned.

This page preserves a source comparison for education. It does not add a rating, recommendation or clinical judgment.

  • Hydrophilic
  • Lys, Arg, Asp, Glu, His
  • Increase solubility
  • Hydrophobic
  • Leu, Ile, Val, Phe, Trp, Tyr
  • Reduce solubility
  • Neutral
  • Gly, Ala, Ser, Thr, Asn, Gln, Pro
  • Context-dependent