Understand the source comparison
How to Increase HGH Naturally with Peptides: Compound Comparison
CJC-1295 (with DAC) GHRH receptor agonist with albumin binding 6–8 days 1–2mg twice weekly Minimal. Transient injection site irritation Best for sustained baseline elevation; twice-weekly dosing offers convenience Modified GRF 1-29 (CJC no DAC) GHRH receptor a
No winner is assigned.
This page preserves a source comparison for education. It does not add a rating, recommendation or clinical judgment.
- CJC-1295 (with DAC)
- GHRH receptor agonist with albumin binding
- 6–8 days
- 1–2mg twice weekly
- Minimal. Transient injection site irritation
- Best for sustained baseline elevation; twice-weekly dosing offers convenience
- Modified GRF 1-29 (CJC no DAC)
- GHRH receptor agonist, no albumin binding
- 30 minutes
- 100–200mcg 1–3x daily
- Minimal. Occasional flushing at high doses
- Best for acute pulsatile stimulation; must be dosed around natural GH peaks
- Ipamorelin
- Ghrelin receptor (GHS-R1a) agonist
- 2 hours
- 200–300mcg 1–3x daily
- Minimal. No cortisol/prolactin elevation
- Best ghrelin mimetic for daily use; selective receptor binding avoids side effects
- Hexarelin
- Ghrelin receptor agonist
- 70 minutes
- 100mcg 1–2x daily
- Receptor desensitization after 4–6 weeks; cortisol elevation possible
- Produces higher peak GH than ipamorelin but limited to short-term use
- MK-677 (Ibutamoren)
- Orally bioavailable ghrelin mimetic
- 24 hours
- 10–25mg once daily
- Elevated cortisol/prolactin in 15–20% of users; increased appetite; water retention
- Convenient oral dosing but side effect profile limits use in sensitive populations
- GHRP-2
- Non-selective ghrelin receptor agonist
- 100–300mcg 1–3x daily
- Cortisol and prolactin elevation; increased appetite
- Older compound largely replaced by ipamorelin due to side effects