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Peptide Therapy GuideClear peptide education

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How to Detox Your Body with Peptides: Full Protocol Comparison

The table below compares the most researched peptides for detoxification support. Mechanism, dosing structure, and evidence quality. Reduced Glutathione (GSH) Phase II liver enzyme substrate (glutathione S-transferase). Conjugates lipophilic toxins for renal e

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  • The table below compares the most researched peptides for detoxification support. Mechanism, dosing structure, and evidence quality.
  • Reduced Glutathione (GSH)
  • Phase II liver enzyme substrate (glutathione S-transferase). Conjugates lipophilic toxins for renal excretion
  • 500–1000mg IV or liposomal, twice daily
  • Strong. RCTs show 40–60% increase in hepatic GSH levels within 7 days
  • Gold standard for acute detoxification support. Bioavailability is dosage-limiting factor
  • Epitalon (Ala-Glu-Asp-Gly)
  • Telomerase activation in hepatocytes and immune cells. Extends replicative capacity of detox-critical cells
  • 5–10mg subcutaneous, 10-day cycles every 4–6 months
  • Moderate. Rodent models show restored phase II enzyme activity in aged liver tissue
  • Best for sustained detoxification capacity in aging or chronically stressed systems
  • Thymosin Alpha-1 (Tα1)
  • Immune surveillance upregulation. Enhances clearance of senescent cells and intracellular toxins via IL-2/IFN-γ pathways
  • 1.6mg subcutaneous, 2–3× weekly for 4–8 weeks
  • Strong. FDA-approved in multiple countries for immune modulation; detox effects are secondary outcome data
  • Synergistic with glutathione for immune-mediated toxin clearance
  • SS-31 (Elamipretide)
  • Mitochondrial membrane stabilization. Reduces oxidative phosphorylation byproducts and supports ATP-dependent detox processes
  • 5–40mg subcutaneous daily for 4–6 weeks
  • Emerging. Phase II trials show improved mitochondrial function markers; detox-specific data limited
  • Strongest mechanism for mitochondrial toxin clearance but requires longer cycles to observe benefit
  • Thymalin (Thymic Peptide Bioregulator)
  • T-cell differentiation and immune surveillance. Supports clearance of damaged cells accumulating metabolic waste
  • 10mg intramuscular or subcutaneous, 10-day cycles
  • Moderate. Eastern European research shows immune restoration in aged populations; detox outcomes are secondary
  • Complements Tα1 for immune-based detoxification pathways