Understand the source comparison
HMG versus recombinant gonadotropins
Recombinant FSH preparations like follitropin alpha provide pure FSH without LH activity, manufactured through genetic engineering rather than extraction from biological sources. These preparations offer consistency and purity advantages but lack the LH compon
No winner is assigned.
This page preserves a source comparison for education. It does not add a rating, recommendation or clinical judgment.
- Recombinant FSH preparations like follitropin alpha provide pure FSH without LH activity, manufactured through genetic engineering rather than extraction from biological sources. These preparations offer consistency and purity advantages but lack the LH component present in HMG. For applications requiring both FSH and LH, recombinant preparations require combining separate products.
- HMG provides convenience through combined FSH and LH in single preparation, though the exact ratio may vary slightly between batches due to biological source variability. Pharmaceutical grade HMG undergoes quality control ensuring consistent potency, but the natural origin means complete standardization remains challenging compared to recombinant products.
- Cost considerations often favor HMG over recombinant preparations, particularly when both FSH and LH activity are desired. The peptide cost calculator can help compare expenses across different protocol approaches, though gonadotropin costs typically exceed most research peptides.