Understand the source comparison
Grow Hair Back with Peptides: Peptide Comparison by Mechanism
GHK-Cu (Copper Peptide) Stimulates VEGF and TGF-β production; increases perifollicular capillary density Topical (1.5–3%) with microneedling 12–16 weeks Moderate. Multiple small-scale RCTs show 40–60% follicular density improvement Best for early-stage miniatu
No winner is assigned.
This page preserves a source comparison for education. It does not add a rating, recommendation or clinical judgment.
- GHK-Cu (Copper Peptide)
- Stimulates VEGF and TGF-β production; increases perifollicular capillary density
- Topical (1.5–3%) with microneedling
- 12–16 weeks
- Moderate. Multiple small-scale RCTs show 40–60% follicular density improvement
- Best for early-stage miniaturisation; requires consistent microneedling for penetration
- TB-500 (Thymosin Beta-4)
- Promotes actin polymerization and extracellular matrix remodeling in keratinocytes
- Subcutaneous injection (2mg 2×/week)
- 16–24 weeks
- Moderate. Phase 2 pilot data shows 18% terminal hair count increase
- Most effective for advanced miniaturisation; subcutaneous delivery is non-negotiable
- PTD-DBM (Prostaglandin Biomimetic)
- Activates prostaglandin F2α receptors to shift follicles from catagen to anagen
- Topical (0.5% daily)
- 20–24 weeks
- Weak. Early-phase trials only; no large-scale replication yet
- Promising mechanism but limited data; wait for Phase 3 results before prioritising
- IGF-1 (Insulin-Like Growth Factor-1)
- Directly stimulates follicular stem cell proliferation and dermal papilla cell activity
- Topical or subcutaneous (case-dependent)
- 12–20 weeks
- Weak. Mostly observational studies; peptide instability limits practical use
- Theoretically potent but stability issues make it unreliable outside research settings