Understand the source comparison
Glow Stack Skin Health: Peptide Types Comparison
Ultrashort Peptides (dipeptides, tripeptides) 200–500 Da Rapid signaling, minimal structural Papillary dermis (reaches within 15–20 min) Immediately post-cleanse on damp skin Best for acute inflammation signaling, poor for sustained collagen upregulation Short
No winner is assigned.
This page preserves a source comparison for education. It does not add a rating, recommendation or clinical judgment.
- Ultrashort Peptides (dipeptides, tripeptides)
- 200–500 Da
- Rapid signaling, minimal structural
- Papillary dermis (reaches within 15–20 min)
- Immediately post-cleanse on damp skin
- Best for acute inflammation signaling, poor for sustained collagen upregulation
- Short-Chain Bioregulators (Cartalax, Matrixyl)
- 500–1,500 Da
- Fibroblast activation, collagen gene expression
- Viable epidermis to upper dermis (30–40 min)
- After hyaluronic acid, before ceramides
- Gold standard for evidence-based anti-aging protocols
- Copper Peptides (GHK-Cu)
- 340 Da (peptide) + copper ion
- Wound healing, antioxidant, metalloproteinase regulation
- Epidermis (copper ion can reach deeper via active transport)
- Evening application, pH 5.5–6.0 vehicle required
- Potent but unstable. Degrades rapidly in suboptimal formulations
- Medium-Chain Peptides (hexapeptides, heptapeptides)
- 2,000–5,000 Da
- Neurotransmitter modulation (Botox-alternative action)
- Requires penetration enhancers to reach dermis
- With lipid carrier or after barrier-disrupting actives
- Marketing often exceeds clinical evidence for wrinkle depth reduction