Understand the source comparison
[Full Keyword]: Compound Comparison
DSIP (Delta Sleep-Inducing Peptide) Modulates corticotropin release, reduces cortisol-driven sleep fragmentation 1–2 nmol/kg subcutaneous, 30–60 min before sleep 7–14 days for polysomnography changes Extends slow-wave sleep duration by 15–23%, reduces sleep on
No winner is assigned.
This page preserves a source comparison for education. It does not add a rating, recommendation or clinical judgment.
- DSIP (Delta Sleep-Inducing Peptide)
- Modulates corticotropin release, reduces cortisol-driven sleep fragmentation
- 1–2 nmol/kg subcutaneous, 30–60 min before sleep
- 7–14 days for polysomnography changes
- Extends slow-wave sleep duration by 15–23%, reduces sleep onset latency
- Best-evidenced peptide for sleep architecture improvement. Zero tolerance development across 12-week trials
- Epithalon (Epitalon)
- Upregulates telomerase, normalizes age-related melatonin decline
- 5–10mg subcutaneous daily for 10–20 days, then 4–6 month washout
- 5–7 days for subjective improvement, peak at day 10–12
- Restores circadian rhythm synchronization in aging populations
- Ideal for circadian misalignment or age-related melatonin disruption. Not for acute insomnia
- Selank
- Increases BDNF expression, reduces amygdala hyperactivity
- 300–900 mcg intranasal, 1–2x daily
- 30–60 min for anxiolytic effect, 2–3 weeks for sleep restructuring
- Reduces stress-induced sleep latency by 34% without GABAergic sedation
- Superior for anxiety-driven insomnia. No dependency risk vs benzodiazepines
- MK 677 (Ibutamoren)
- Growth hormone secretagogue, increases REM and slow-wave amplitude
- 10–25mg oral before bed
- 7 days for detectable changes, peak at 4–6 weeks
- Increases REM duration and slow-wave sleep depth
- Dual benefit for recovery and sleep quality. Requires consistent daily dosing
- Thymalin
- Immune modulation, cortisol normalization
- 5–10mg subcutaneous 2–3x weekly
- 10–14 days for immune pathway effects
- Reduces immune-driven sleep fragmentation
- Addresses upstream immune-cortisol dysregulation. Indirect but sustainable