Understand the source comparison
Follistatin-344 Quality Real vs Fake: Detailed Comparison
This table compares genuine research-grade follistatin-344 against common counterfeit or low-quality versions across critical quality indicators. Synthesis Method Solid-phase peptide synthesis with 99%+ coupling efficiency per residue, verified by mass spec at
No winner is assigned.
This page preserves a source comparison for education. It does not add a rating, recommendation or clinical judgment.
- This table compares genuine research-grade follistatin-344 against common counterfeit or low-quality versions across critical quality indicators.
- Synthesis Method
- Solid-phase peptide synthesis with 99%+ coupling efficiency per residue, verified by mass spec at multiple checkpoints
- Liquid-phase synthesis or solid-phase with incomplete coupling, no intermediate verification
- Solid-phase synthesis is non-negotiable—liquid-phase cannot achieve the sequence accuracy required for 344 residues
- Purity Verification
- Third-party HPLC showing >98% purity, single dominant peak, molecular weight 37.8 kDa ±50 Da confirmed by mass spectrometry
- In-house testing only, or no documentation provided; purity claims without chromatogram evidence
- Without third-party HPLC, purity claims are unverifiable—synthesis errors and degradation go undetected
- Endotoxin Level
- <1 EU/mg confirmed by limulus amebocyte lysate assay, documented in certificate of analysis
- Not tested, or levels exceed 5 EU/mg due to non-sterile lyophilization conditions
- Endotoxin contamination above 5 EU/mg confounds research results through inflammatory pathway activation
- Cold Chain Storage
- Shipped at −20°C with insulated packaging and gel packs, delivered within 48–72 hours with tracking
- Shipped at ambient temperature via standard mail, or cold packs insufficient for transit duration
- Single temperature excursion above 8°C during shipping can denature peptide structure irreversibly
- Reconstitution Clarity
- Dissolves completely in bacteriostatic water within 60 seconds, forming clear colorless solution with no particulates
- Persistent cloudiness, visible particles, or incomplete dissolution indicating protein aggregation from degradation
- Reconstitution failure is immediate evidence of degradation—aggregated protein cannot bind target receptors
- Documentation Provided
- Certificate of analysis with HPLC chromatogram, mass spec molecular weight, endotoxin test results, storage instructions
- Generic label with claimed dose and purity, no third-party verification or batch-specific data
- Suppliers who won't provide batch-specific documentation have no quality accountability