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Fight Chronic Fatigue with Peptides: Mechanism Comparison
Thymic Peptides (Thymalin) Restores thymic epithelial function and T-cell differentiation Immune regulation. Reduces inflammatory cytokine load 3–4 weeks Every other day for 10 doses, then weekly maintenance Most effective for immune-driven fatigue with post-e
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- Thymic Peptides (Thymalin)
- Restores thymic epithelial function and T-cell differentiation
- Immune regulation. Reduces inflammatory cytokine load
- 3–4 weeks
- Every other day for 10 doses, then weekly maintenance
- Most effective for immune-driven fatigue with post-exertional malaise and frequent infections
- Growth Hormone Secretagogues (MK-677)
- Stimulates pulsatile GH/IGF-1 secretion and restores glucocorticoid sensitivity
- HPA axis function. Normalizes cortisol rhythm
- 4–6 weeks
- Once daily oral dosing
- Best for HPA axis dysfunction with cortisol rhythm collapse and orthostatic intolerance
- Neurotrophic Peptides (Cerebrolysin, Dihexa)
- Upregulates PGC-1alpha to increase mitochondrial biogenesis
- Mitochondrial density. Improves cellular ATP production capacity
- 6–8 weeks
- 5 days per week for 4 weeks, then observation period
- Required for mitochondrial insufficiency but slowest mechanism. Needs sequential use after immune/HPA correction
- Metabolic Modulators (SLU PP 332, Survodutide)
- Enhances mitochondrial respiration and oxidative capacity
- Energy substrate utilization. Improves ATP output per mitochondrion
- Varies by compound. Typically daily to twice weekly
- Addresses energy efficiency when mitochondrial density is adequate but function is impaired