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Fasted vs Fed State Administration
Oral bioavailability of SS-LUP-332 drops approximately 30-40% when administered with food, particularly high-fat meals. A small pharmacokinetics study (n=16) found that co-administration with a 600-calorie meal containing 25g fat reduced peak plasma concentrat
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- Oral bioavailability of SS-LUP-332 drops approximately 30-40% when administered with food, particularly high-fat meals. A small pharmacokinetics study (n=16) found that co-administration with a 600-calorie meal containing 25g fat reduced peak plasma concentration by 38% and delayed Tmax (time to peak concentration) from 90 minutes to 180 minutes. For researchers dosing pre-training, this creates a practical constraint: either dose 90 minutes pre-training on an empty stomach, or dose 3+ hours pre-training with food and accept delayed absorption.
- Most current protocols use fasted-state dosing 60-90 minutes before training, then allow normal post-workout nutrition without restriction. The compound is fully absorbed by that point, and post-exercise protein/carbohydrate intake doesn't interfere with its mechanism. One caveat: subjects prone to GI sensitivity sometimes experience mild nausea when taking 20mg+ doses on an empty stomach—mitigated by taking the dose with 100-150ml water and a small amount of easily digestible carbohydrate (white rice, banana) 15-20 minutes after administration, which minimally affects absorption but reduces gastric discomfort.