Understand the source comparison
DSIP Biomarkers: Research Methods Comparison
Cortisol suppression (ACTH challenge) Serum cortisol at 0, 30, 60 min post-ACTH 35–48% reduction in peak cortisol 30–60 minutes post-ACTH High. Validated across 12+ controlled trials REM sleep latency Polysomnography (EEG, EOG) 15–25 minute reduction in time t
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- Cortisol suppression (ACTH challenge)
- Serum cortisol at 0, 30, 60 min post-ACTH
- 35–48% reduction in peak cortisol
- 30–60 minutes post-ACTH
- High. Validated across 12+ controlled trials
- REM sleep latency
- Polysomnography (EEG, EOG)
- 15–25 minute reduction in time to first REM
- First sleep cycle (60–90 min post-onset)
- High. Consistent across sleep lab studies
- Plasma catecholamines
- HPLC analysis (norepinephrine, epinephrine)
- 20–30% blunted stress response
- 10–20 minutes post-stressor
- Moderate. Fewer studies, reproducible effect
- Beta-endorphin increase
- Radioimmunoassay (plasma samples)
- 15–25% elevation from baseline
- 45–90 minutes post-administration
- Emerging. Data from 4–6 research groups
- Slow-wave sleep percentage
- Polysomnography (delta wave amplitude)
- 4–7% absolute increase in SWS %
- Throughout sleep period
- Moderate. Effect size smaller, variable across subjects