Understand the source comparison
Does NAD+ Help Addiction Recovery Research? — IV vs Oral NAD+ Comparison
Intravenous Infusion 100% (bypasses gut metabolism) 500–1,500 mg over 4–8 hours 400–600% above baseline 12–18 hours post-infusion Highest efficacy for acute withdrawal. Allows precise dose titration and immediate systemic delivery. Most clinical trial data use
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This page preserves a source comparison for education. It does not add a rating, recommendation or clinical judgment.
- Intravenous Infusion
- 100% (bypasses gut metabolism)
- 500–1,500 mg over 4–8 hours
- 400–600% above baseline
- 12–18 hours post-infusion
- Highest efficacy for acute withdrawal. Allows precise dose titration and immediate systemic delivery. Most clinical trial data uses this route.
- Sublingual NAD+
- 10–20% (partial first-pass bypass)
- 50–100 mg daily
- 50–80% above baseline
- 4–6 hours
- Moderate efficacy for maintenance protocols. Convenience favors compliance but lower peak levels limit acute symptom relief.
- Oral Capsules (NAD+ direct)
- <5% (degraded by stomach acid and liver metabolism)
- 100–300 mg daily
- 10–20% above baseline
- 2–4 hours
- Least effective. Most NAD+ is broken down before reaching systemic circulation. Better for long-term maintenance than acute intervention.
- Oral NAD+ Precursors (NR, NMN)
- 40–60% (converted to NAD+ intracellularly)
- 250–500 mg daily
- 100–150% above baseline
- 6–10 hours
- Most practical for outpatient protocols. Reliable bioavailability, lower cost, and evidence of sustained NAD+ elevation over weeks.