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Peptide Therapy GuideClear peptide education

Understand the source comparison

Doctors Prescribe Peptides Off Label: Comparison

GLP-1 Agonists (semaglutide, tirzepatide) Type 2 diabetes, obesity (Wegovy only) Metabolic dysfunction, NAFLD, cardiovascular risk reduction GLP-1 receptors in hepatic tissue regulate lipid metabolism and insulin sensitivity beyond glycemic control alone Basel

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This page preserves a source comparison for education. It does not add a rating, recommendation or clinical judgment.

  • GLP-1 Agonists (semaglutide, tirzepatide)
  • Type 2 diabetes, obesity (Wegovy only)
  • Metabolic dysfunction, NAFLD, cardiovascular risk reduction
  • GLP-1 receptors in hepatic tissue regulate lipid metabolism and insulin sensitivity beyond glycemic control alone
  • Baseline liver enzymes, lipid panel, documented metabolic syndrome criteria
  • Strong mechanistic support. Hepatic GLP-1 receptor density justifies NAFLD application even without formal approval
  • Growth Hormone Secretagogues (MK 677)
  • None (investigational status in U.S.)
  • Age-related muscle loss, sleep disorders, bone density maintenance
  • Ghrelin receptor agonism increases endogenous GH pulse frequency and IGF-1, stimulating muscle protein synthesis and stage 3/4 sleep
  • Baseline IGF-1, DEXA scan, polysomnography if sleep-focused
  • Moderate support. Mechanism clear, but long-term safety data limited outside research settings
  • Nootropic Peptides (Cerebrolysin, Dihexa)
  • Stroke recovery (Cerebrolysin in select countries)
  • Cognitive decline, traumatic brain injury, neurodegenerative disease
  • BDNF upregulation and synaptic plasticity enhancement through neurotrophic signaling
  • Baseline cognitive testing (MoCA or equivalent), documented progressive decline
  • Emerging evidence. Cerebrolysin has RCT support in stroke; Dihexa remains investigational with limited human data
  • Immune Modulators (Thymalin)
  • None (research use in Russia)
  • Immune senescence, autoimmune flare prevention, post-viral fatigue
  • Thymic peptide restoration enhances T-cell differentiation and regulatory T-cell function
  • Baseline immunoglobulin levels, T-cell subset panel, documented immune dysfunction
  • Weak formal evidence. Mechanistic rationale exists but lacks robust Phase 3 data in Western literature