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Do Peptides Help with Longevity: Research Peptide Comparison
Before the table: This comparison covers the five peptide categories with the strongest mechanistic rationale for longevity intervention. Immune restoration, telomere preservation, mitochondrial efficiency, neurodegeneration prevention, and metabolic regulatio
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- Before the table: This comparison covers the five peptide categories with the strongest mechanistic rationale for longevity intervention. Immune restoration, telomere preservation, mitochondrial efficiency, neurodegeneration prevention, and metabolic regulation. Each peptide is assessed on its primary aging target, documented human evidence, and administration practicality.
- Thymosin Alpha-1 (Thymalin)
- Thymic involution, immune senescence
- Phase 3 trials in elderly populations. 30–40% reduction in infection mortality
- Subcutaneous injection, 1–2mg twice weekly
- Strongest evidence for immune system restoration in aging populations. Measurable clinical endpoints
- Epithalon
- Telomere attrition, pineal function
- Russian clinical trials showing 6–8% telomere lengthening. Limited Western replication
- Subcutaneous injection, 10-day cycles every 4–6 months
- Mechanistically sound but long-term safety data in diverse populations incomplete
- MOTS-c
- Mitochondrial translation efficiency, metabolic health
- Phase 2 metabolic studies. Improved insulin sensitivity and VO2 max in middle-aged adults
- Subcutaneous injection, 5–15mg 2–3× weekly
- Strong biomarker evidence for metabolic preservation. Lifespan data still pending
- Cerebrolysin
- Neuronal repair, neurotrophic signaling
- Meta-analysis of 23 trials in neurodegenerative conditions. Modest cognitive improvements
- Intravenous or intramuscular injection, clinical supervision required
- Evidence supports neuroprotection in pathological aging. Unclear benefit in healthy aging
- GHK-Cu (Copper Peptide)
- Collagen synthesis, tissue repair signaling
- Dermatological studies on wound healing and skin aging. Minimal systemic longevity data
- Topical or subcutaneous injection
- Well-documented for localized tissue repair. Extrapolation to systemic longevity speculative