Understand the source comparison
Dihexa for HGF Mimetic: Research Comparison Table
Molecular Weight <600 Da ~80,000 Da ~27,000 Da ~26,000 Da Dihexa's small size enables BBB penetration unavailable to endogenous growth factors Blood-Brain Barrier Penetration High (passive diffusion) Negligible Only dihexa achieves CNS bioavailability after sy
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- Molecular Weight
- <600 Da
- ~80,000 Da
- ~27,000 Da
- ~26,000 Da
- Dihexa's small size enables BBB penetration unavailable to endogenous growth factors
- Blood-Brain Barrier Penetration
- High (passive diffusion)
- Negligible
- Only dihexa achieves CNS bioavailability after systemic administration
- Primary Receptor Target
- c-Met tyrosine kinase
- TrkB receptor
- TrkA receptor
- Dihexa replicates HGF's c-Met pathway without requiring endogenous ligand
- Synaptogenesis Potency (Relative to BDNF)
- 7× higher in vitro
- Not directly comparable
- Baseline reference
- ~2× lower than BDNF
- Dihexa produces synaptogenic effects an order of magnitude above BDNF
- Half-Life in Circulation
- 2–4 hours
- 4–6 hours
- <1 minute
- Short plasma half-life, but downstream structural effects persist for days
- Typical Research Dose Range
- 0.05–2.0 mg/kg (animal models)
- N/A (endogenous)
- 1–10 mg/kg (requires CNS delivery)
- 0.1–1 mg/kg (requires CNS delivery)
- Dihexa effective at doses 10–100× lower than other neurotrophic interventions