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Dihexa Before and After: Dosing Comparison
Different Dihexa dosing protocols produce distinct timelines and effect magnitudes. This table summarizes findings from published preclinical studies to guide protocol design. 1.0 IP 14 days 62% reduction in Morris water maze latency (Harding 2014) Day 14 Main
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- Different Dihexa dosing protocols produce distinct timelines and effect magnitudes. This table summarizes findings from published preclinical studies to guide protocol design.
- 1.0
- IP
- 14 days
- 62% reduction in Morris water maze latency (Harding 2014)
- Day 14
- Maintained at day 28
- Optimal dose for spatial learning enhancement. Steep inverted-U curve
- 4.0
- 34% reduction in Morris water maze latency (Harding 2014)
- Reduced by day 28
- Diminishing returns at high dose. Lower efficacy than 1mg/kg
- 0.5
- 21 days
- 68% novel object preference (TBI model, Peptides 2016)
- Day 28
- Not reported
- Effective neuroprotective dose in injury models. Lower than cognition-only protocols
- 3–5
- Oral
- Equivalent to ~1mg/kg IP (PK study 2015)
- Day 14–21
- Oral bioavailability ~25%. Requires 3–4× IP dose for equivalent exposure
- 0.04
- No measurable effect (Harding 2014)
- N/A
- Below threshold. C-Met activation insufficient for synaptogenesis
- 7 days
- Duration too short for structural remodeling. Requires ≥14 days