Understand the source comparison
Comprehensive Reference: Published Science vs Internet Protocol
One table, side by side. The left column is peer-reviewed. The right column is marketing. Species Mouse (C57BL/6, DIO, ob/ob) Human Route Intraperitoneal injection Subcutaneous injection Dose 50 mg/kg, twice daily 500 to 1,500 mcg total per day Human-equivalen
No winner is assigned.
This page preserves a source comparison for education. It does not add a rating, recommendation or clinical judgment.
- One table, side by side. The left column is peer-reviewed. The right column is marketing.
- Species
- Mouse (C57BL/6, DIO, ob/ob)
- Human
- Route
- Intraperitoneal injection
- Subcutaneous injection
- Dose
- 50 mg/kg, twice daily
- 500 to 1,500 mcg total per day
- Human-equivalent of the mouse dose
- ~650 mg/day for an 80 kg adult
- ~430x lower than that
- Vehicle
- Laboratory solubilizing vehicle
- Bacteriostatic water, or DMSO
- Longest exposure
- 28 days
- 8 to 12 week "cycles"
- Dosing frequency rationale
- Twice daily, per protocol
- 2 to 3x daily, from a rodent half-life
- Endpoint measured
- Treadmill distance, fat mass, glucose tolerance
- Subjective endurance and fat loss
- Safety monitoring
- Plasma cholesterol, liver enzymes, histology
- None
- Toxicology
- No carcinogenicity, no reprotox, no chronic study
- Not mentioned
- Human PK
- None exists
- Half-life quoted from rodents
- Regulatory status
- Unapproved. No IND, no Phase 1
- "Research use only" disclaimer
- Now place it against compounds with actual human evidence:
- SLU-PP-332
- Small molecule, pan-ERR agonist
- Research chemical
- Tirzepatide
- Peptide, GIP/GLP-1 agonist
- Phase 3, tens of thousands
- FDA approved
- Retatrutide
- Peptide, triple agonist
- Phase 2 complete, Phase 3 running
- Investigational
- Cagrilintide
- Peptide, amylin analog
- Phase 2 and 3
- 5-Amino-1MQ
- Small molecule, NNMT inhibitor
- MOTS-c
- Mitochondrial peptide
- Minimal
- Two entries on that list are also small molecules dressed up as peptides. 5-Amino-1MQ is an NNMT inhibitor with the same evidence problem. We have flagged this pattern before with lipo-C, which is a MIC plus B12 blend, and pinealon, whose evidence base is preclinical and largely Russian. On these storefronts, the word "peptide" describes a shelf.
- If endurance and mitochondrial function are the actual goal, the interventions with the most human support remain the boring ones: structured training, sleep, and the metabolic drugs carrying Phase 3 files. See peptides for recovery, peptides for energy, and peptides vs steroids for how these categories differ in evidence and risk.