Understand the source comparison
Comparison with Other GHRPs
GHRP-2: More potent than ipamorelin for GH release but significant cortisol and prolactin elevation. Research requiring GH stimulation without HPA axis activation favors ipamorelin. GHRP-6: Classic reference compound; produces significant ghrelin-like appetite
No winner is assigned.
This page preserves a source comparison for education. It does not add a rating, recommendation or clinical judgment.
- GHRP-2: More potent than ipamorelin for GH release but significant cortisol and prolactin elevation. Research requiring GH stimulation without HPA axis activation favors ipamorelin.
- GHRP-6: Classic reference compound; produces significant ghrelin-like appetite stimulation through peripheral GHSR-1a, unlike ipamorelin which shows less pronounced appetite effects.
- Hexarelin: Most potent GHRP but develops rapid desensitization (tachyphylaxis) and has significant cardiovascular effects through CD36 receptor binding — distinct from ipamorelin's cleaner GHSR-1a profile.
- MK-677 (Ibutamoren): Oral GHSR-1a agonist with similar selectivity to ipamorelin but much longer half-life (~24 hours), enabling oral administration — relevant for research where subcutaneous injections are impractical.