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Comparison to clomiphene citrate
A retrospective study comparing enclomiphene to traditional clomiphene citrate found meaningful differences in both effectiveness and tolerability. Enclomiphene produced a median testosterone increase of 166 ng/dL with lower estradiol changes compared to clomi
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- A retrospective study comparing enclomiphene to traditional clomiphene citrate found meaningful differences in both effectiveness and tolerability.
- Enclomiphene produced a median testosterone increase of 166 ng/dL with lower estradiol changes compared to clomiphene. More importantly, estradiol actually decreased slightly with enclomiphene while increasing with clomiphene. This difference explains much of the tolerability advantage.
- Adverse effects were significantly less frequent with enclomiphene. Decreased libido occurred in far fewer enclomiphene users. Energy reduction was less common. Mood changes were less frequent. These differences reflect the absence of the zuclomiphene isomer and its estrogenic activity.