Understand the source comparison
Comparison: Peptides for Leaky Gut Restoration
BPC-157 VEGF upregulation, collagen synthesis, tight junction protein expression (occludin, claudin) 500–1000 mcg daily (split into 2 doses) 4–6 hours Subcutaneous (lower abdomen preferred) Gold standard for structural gut repair. Most robust preclinical evide
No winner is assigned.
This page preserves a source comparison for education. It does not add a rating, recommendation or clinical judgment.
- BPC-157
- VEGF upregulation, collagen synthesis, tight junction protein expression (occludin, claudin)
- 500–1000 mcg daily (split into 2 doses)
- 4–6 hours
- Subcutaneous (lower abdomen preferred)
- Gold standard for structural gut repair. Most robust preclinical evidence for epithelial barrier restoration
- KPV
- NF-κB inhibition, reduces pro-inflammatory cytokine release in gut mucosa
- 250–500 mcg daily
- 2–4 hours
- Subcutaneous or oral (enteric-coated)
- Best for inflammation-dominant leaky gut. Works locally when administered orally, systemically when injected
- Thymosin Beta-4 (TB-500)
- Actin upregulation, promotes epithelial migration and wound closure
- 2–5 mg weekly
- 24–48 hours
- Subcutaneous or intramuscular
- Broader tissue repair peptide. Gut healing is secondary benefit, not primary mechanism
- Thymalin
- Thymic peptide complex, immune modulation in GALT (gut-associated lymphoid tissue)
- 5–10 mg every 3–5 days
- 12–18 hours
- Targets immune dysregulation in gut. Thymalin is ideal for autoimmune-driven permeability