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Peptide Therapy GuideClear peptide education

Understand the source comparison

Comparison of BDNF-boosting peptides

The following comparison helps illustrate the relative strengths and research maturity of each compound. Researchers using the peptide stack calculator can use this information to guide protocol design. Peptide Primary mechanism BDNF effect Administration Rese

No winner is assigned.

This page preserves a source comparison for education. It does not add a rating, recommendation or clinical judgment.

  • The following comparison helps illustrate the relative strengths and research maturity of each compound. Researchers using the peptide stack calculator can use this information to guide protocol design.
  • Peptide
  • Primary mechanism
  • BDNF effect
  • Administration
  • Research maturity
  • Semax
  • Neurotrophic modulation
  • 1.4-fold protein, 3-fold mRNA
  • Intranasal
  • Clinical use (Russia)
  • Selank
  • GABAergic + neurotrophic
  • Rapid hippocampal elevation
  • Noopept
  • NGF + BDNF upregulation
  • Chronic hippocampal increase
  • Oral, sublingual
  • Dihexa
  • HGF/c-Met potentiation
  • 10M x more potent synaptogenesis
  • Oral, injection
  • Preclinical only
  • PE-22-28
  • TrkB + TREK-1 modulation
  • Rapid hippocampal increase
  • Subcutaneous
  • Pinealon
  • Gene expression modulation
  • Oral, intranasal
  • Preclinical