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Cartalax Anti-Aging Research: Model Comparison
In vitro aged fibroblasts 10–50mcg/mL culture medium, 72-hour exposure Collagen Type I mRNA expression, proliferation rate Chromatin remodelling in COL1A1 gene promoter region 48–72 hours Aged rodent muscle tissue 100mcg subcutaneous, 10-day cycles Cross-secti
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- In vitro aged fibroblasts
- 10–50mcg/mL culture medium, 72-hour exposure
- Collagen Type I mRNA expression, proliferation rate
- Chromatin remodelling in COL1A1 gene promoter region
- 48–72 hours
- Aged rodent muscle tissue
- 100mcg subcutaneous, 10-day cycles
- Cross-sectional muscle fiber area, satellite cell activation
- Myogenic transcription factor upregulation (MyoD, Myf5)
- 14–21 days
- Human mesenchymal stem cells
- 20mcg/mL, continuous 14-day culture
- Differentiation capacity, senescence marker expression (p16, p21)
- Restoration of multipotency through epigenetic modification
- 7–14 days
- Cartilage explant models
- 50mcg/mL in culture media, 21-day exposure
- Proteoglycan synthesis, aggrecan gene expression
- Transcriptional activation of cartilage matrix genes
- 10–21 days