Understand the source comparison
Best SS-LUP-332 Dosage for ERR Agonist: Comparison Across Study Models
Murine skeletal muscle biogenesis 20–25 mg/kg daily Mitochondrial DNA copy number, COX4/TFAM mRNA, VO2max 2 hours into dark phase Gold standard for endurance and mitochondrial density studies. Doses above 25 mg/kg show diminishing returns Hepatic metabolic dys
No winner is assigned.
This page preserves a source comparison for education. It does not add a rating, recommendation or clinical judgment.
- Murine skeletal muscle biogenesis
- 20–25 mg/kg daily
- Mitochondrial DNA copy number, COX4/TFAM mRNA, VO2max
- 2 hours into dark phase
- Gold standard for endurance and mitochondrial density studies. Doses above 25 mg/kg show diminishing returns
- Hepatic metabolic dysfunction (NAFLD models)
- 15–20 mg/kg daily
- Hepatic triglyceride content, β-oxidation enzyme expression, insulin sensitivity
- Early dark phase or ZT13–15
- Lower dose sufficient due to higher baseline ERRγ expression in liver tissue
- Brown adipose thermogenesis
- UCP1 protein expression, oxygen consumption in BAT, core body temperature
- Mid-dark phase during peak metabolic activity
- Requires upper dosing range. Adipose ERR receptor density is ~40% lower than muscle
- Acute mitochondrial respiration (single-dose)
- 30–40 mg/kg single administration
- Real-time oxygen flux via Oroboros Oxygraph, complex I/II activity
- 3 hours prior to tissue harvest
- Higher single doses acceptable for acute mechanistic studies. Chronic use at this range triggers feedback inhibition