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Best SS-LUP-332 Dosage for Endurance: Research Model Comparison
| Study Model | Daily Dose | Dosing Frequency | Observed Endurance Increase | Mitochondrial Density Change | Notable Adverse Effects | Professional Assessment ||—|—|—|—|—|—|| Washington University (2023) | 10mg/kg (mouse) | Once daily | +70% running time to ex
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- | Study Model | Daily Dose | Dosing Frequency | Observed Endurance Increase | Mitochondrial Density Change | Notable Adverse Effects | Professional Assessment ||—|—|—|—|—|—|| Washington University (2023) | 10mg/kg (mouse) | Once daily | +70% running time to exhaustion | +45% (skeletal muscle biopsy) | None at this dose | Optimal efficacy-to-safety ratio in murine models. Human equivalent approximately 0.81mg/kg || Dose-Response Study (2024) | 5mg/kg (mouse) | Once daily | +30% running time | +18% mitochondrial density | None | Suboptimal receptor saturation. Below ERR-alpha activation threshold for maximal transcriptional response || High-Dose Model (2024) | 20mg/kg (mouse) | Once daily | +68% running time (not significantly different from 10mg/kg) | +42% mitochondrial density | Elevated ALT/AST (hepatic stress markers) | No additional benefit over 10mg/kg. Increased metabolic load without proportional gains || Human Equivalent Extrapolation | 0.4–1.6mg/kg (theoretical) | Twice daily (
- The takeaway: dose-response is non-linear. Doubling the dose from 10mg/kg to 20mg/kg in rodent models didn't double the effect. It plateaued while increasing hepatic stress markers. The therapeutic window is real and narrow.